Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655830 | 0.86 | SMN1; SMN2 (0.44) | GAAPOLBALDH1A1LMNAMAPT | |
| Bromide SCHEMBL7657001 | 0.85 | SMN1; SMN2 (0.43) | GAAPOLBALDH1A1LMNAMAPT | |
| SCHEMBL7656229 | 0.83 | GAA (0.46) | GAAPOLBRAPGEF4F2ALDH1A1 | |
| SCHEMBL7657031 | 0.83 | GAA (0.50) | GAAPOLBRAPGEF4F2ALDH1A1 | |
| SCHEMBL10126485 | 0.82 | GUCY1A1 (0.55) | GAARAPGEF4ALDH1A1LMNAMAPT | |
| SCHEMBL22791495 | 0.80 | GAA (0.58) | GAAPOLBRAPGEF4F2ALDH1A1 | |
| SCHEMBL16301229 | 0.80 | LMNA (0.50) | GAAPOLBRAPGEF4F2ALDH1A1 | |
| SCHEMBL7653266 | 0.80 | GAA (0.48) | GAAPOLBRAPGEF4F2ALDH1A1 | |
| SCHEMBL7655781 | 0.79 | NSD2 (0.44) | GAAPOLBRAPGEF4F2ALDH1A1 | |
| SCHEMBL20673500 | 0.79 | FERMT2 (0.50) | GAAPOLBRAPGEF4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |