Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAX | Q07812 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL607992 | 0.77 | BAX (0.60) | BAXMAPTCYP3A4TP53ALOX15 | |
| SCHEMBL5024339 | 0.69 | BAX (0.72) | BAXMAPTCYP3A4TP53ALOX15 | |
| SCHEMBL29398838 | 0.69 | BAX (0.72) | BAXMAPTCYP3A4TP53ALOX15 | |
| SCHEMBL607745 | 0.69 | BAX (0.72) | BAXMAPTCYP3A4TP53ALOX15 | |
| SCHEMBL5024320 | 0.69 | BAX (0.72) | BAXMAPTCYP3A4TP53ALOX15 | |
| SCHEMBL29992291 | 0.69 | BAX (0.72) | BAXMAPTCYP3A4TP53ALOX15 | |
| SCHEMBL22261901 | 0.69 | BAX (0.64) | BAXMAPTCYP3A4TP53ALOX15 | |
| Hydrochloric Acid SCHEMBL31038642 | 0.69 | MAPT (0.73) | BAXMAPTCYP3A4TP53ALOX15 | |
| Hydrochloric Acid SCHEMBL29462932 | 0.69 | MAPT (0.73) | BAXMAPTCYP3A4TP53ALOX15 | |
| SCHEMBL608294 | 0.68 | BAX (0.88) | BAXMAPTCYP3A4TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | claimed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | claimed |