Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.44 |
| ▸ | ITGAV | P06756 | 6/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655207 | 0.86 | ITGB3 (0.42) | ITGB3ITGAVITGA2BMAPTALDH1A1 | |
| SCHEMBL7658323 | 0.85 | JAK2 (0.41) | ITGB3ITGAVITGA2BSCN9A | |
| SCHEMBL7654471 | 0.84 | ITGB3 (0.52) | ITGB3ITGAVITGA2BMAPTALDH1A1 | |
| SCHEMBL7649751 | 0.83 | ITGB3 (0.56) | ITGB3ITGAVITGA2BMAPTALDH1A1 | |
| SCHEMBL7655618 | 0.81 | ITGB3 (0.42) | ITGB3ITGAVITGA2BMAPTALDH1A1 | |
| SCHEMBL7655263 | 0.81 | DPP4 (0.42) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL7658791 | 0.80 | ITGB3 (0.44) | ITGB3ITGAVITGA2BMAPTALDH1A1 | |
| SCHEMBL7655184 | 0.77 | ITGB3 (0.55) | ITGB3ITGAVITGA2BMAPTALDH1A1 | |
| SCHEMBL6798625 | 0.75 | ITGB3 (0.62) | ITGB3ITGAVITGA2BHPGDPARP1 | |
| SCHEMBL382678 | 0.74 | ITGB3 (0.44) | ITGB3ITGAVITGA2BMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |