SCHEMBL7654574

SCHEMBL7654574

CC(C)(C)[Si](OCc1c(Cl)ccc(-n2cccc2CNC(=O)/C=C/c2ccc(/C=C/c3ccncc3)nc2)c1Cl)(c1ccccc1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7654575 1.00 BDKRB2 (0.53) BDKRB2
SCHEMBL7017843 0.87 BDKRB2 (0.54) BDKRB2
SCHEMBL7017846 0.87 BDKRB2 (0.54) BDKRB2
SCHEMBL7011413 0.86 BDKRB2 (0.52) BDKRB2
SCHEMBL7011409 0.86 BDKRB2 (0.52) BDKRB2
SCHEMBL7010297 0.86 BDKRB2 (0.65) BDKRB2
SCHEMBL7010302 0.86 BDKRB2 (0.65) BDKRB2
SCHEMBL7009606 0.85 BDKRB2 (0.50) BDKRB2
SCHEMBL7009610 0.85 BDKRB2 (0.50) BDKRB2
SCHEMBL7012120 0.85 BDKRB2 (0.58) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6344462-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-02-05 US disclosed
US-6100284-A ANTIALLERGENS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-08-08 US disclosed
US-6008229-A TREATING ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0861243-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-09-02 EP disclosed
WO-1997011069-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-03-27 WO disclosed