SCHEMBL765490

SCHEMBL765490

COC(=O)c1ccc(CCc2ccccc2)c(-c2c(C)cc(OCCCS(C)(=O)=O)cc2C)c1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 20/20 0.49
FFAR4 Q5NUL3 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL205049 0.88 FFAR1 (0.50) FFAR1
SCHEMBL14319101 0.84 HPGD (0.40) FFAR1
SCHEMBL17385818 0.78 FFAR1 (0.43) FFAR1
SCHEMBL17418097 0.77 FFAR1 (0.41) FFAR1
SCHEMBL17386274 0.75 FFAR1 (0.40) FFAR1
SCHEMBL17418022 0.75 NPC1 (0.42) FFAR1FFAR4
SCHEMBL17429658 0.74 FFAR1 (0.42) FFAR1
SCHEMBL10010164 0.74 FFAR1 (0.48) FFAR1FFAR4
SCHEMBL17418047 0.73 MAPT (0.39) FFAR1FFAR4
SCHEMBL3630085 0.73 LMNA (0.52) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2431367-A2 Fused cyclic compounds as GPR40 receptor modulators Takeda Pharmaceutical Company Limited (JP) 2012-03-21 EP disclosed
WO-2008001931-A2 FUSED CYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-01-03 WO disclosed