Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22805991 | 0.93 | SLC6A2 (0.47) | RIPK1HCRTR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17922881 | 0.89 | RIPK1 (0.51) | RIPK1HCRTR2NPC1MEN1KMT2A | |
| SCHEMBL17922922 | 0.87 | MEN1 (0.51) | RIPK1HCRTR2MEN1KMT2AKLK7 | |
| SCHEMBL9025059 | 0.83 | RIPK1 (0.52) | RIPK1HCRTR2NPC1MEN1KMT2A | |
| SCHEMBL9023721 | 0.83 | RIPK1 (0.52) | RIPK1HCRTR2NPC1MEN1KMT2A | |
| SCHEMBL5784217 | 0.83 | RIPK1 (0.52) | RIPK1HCRTR2NPC1MEN1KMT2A | |
| SCHEMBL9024840 | 0.83 | RIPK1 (0.52) | RIPK1HCRTR2NPC1MEN1KMT2A | |
| SCHEMBL8121365 | 0.83 | RIPK1 (0.52) | RIPK1HCRTR2NPC1MEN1KMT2A | |
| SCHEMBL8125588 | 0.83 | RIPK1 (0.52) | RIPK1HCRTR2NPC1MEN1KMT2A | |
| SCHEMBL9294807 | 0.82 | RIPK1 (0.47) | RIPK1HCRTR2NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372754-B1 | DRUGS FOR TREATMENT OR PREVENTION OF DEPRESSION, ANXIETY, PAIN, INFLAMMATION, MIGRAINE, EMESIS OR POSTHERPIC NEURALGIA. | MERCK SHARP & DOHME LTD. | 2002-04-16 | — | — | US | disclosed |