Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653615 | 0.82 | PDCD1 (0.40) | PNPPDCD1CD274ESR1ESR2 | |
| SCHEMBL7108544 | 0.80 | PNP (0.36) | PNP | |
| SCHEMBL7106706 | 0.80 | PNP (0.31) | PNP | |
| SCHEMBL7107796 | 0.78 | — | — | |
| SCHEMBL7109158 | 0.77 | PNP (0.46) | PNP | |
| SCHEMBL7655218 | 0.76 | GRIN2D (0.39) | PNPPDCD1CD274 | |
| SCHEMBL7103584 | 0.73 | PNP (0.44) | PNP | |
| SCHEMBL7110095 | 0.73 | MTAP (0.34) | PNP | |
| SCHEMBL7656354 | 0.72 | PNP (0.36) | PNPPDCD1CD274 | |
| SCHEMBL7108600 | 0.71 | TYMP (0.41) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |