Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654981 | 0.82 | PNP (0.41) | PDCD1CD274PNPESR1ESR2 | |
| SCHEMBL7654585 | 0.81 | PNP (0.41) | PDCD1CD274PNPKMT2AMAPT | |
| SCHEMBL7661935 | 0.79 | ESR1 (0.30) | ESR1ESR2 | |
| SCHEMBL7652140 | 0.75 | PNP (0.39) | PDCD1CD274PNPKMT2AMAPT | |
| SCHEMBL7650963 | 0.75 | KMT2A (0.39) | KMT2AMAPTMEN1LMNAKDM4E | |
| SCHEMBL7658936 | 0.73 | KMT2A (0.45) | KMT2AMAPTMEN1LMNAALDH1A1 | |
| SCHEMBL7108544 | 0.72 | PNP (0.36) | PNP | |
| SCHEMBL5209583 | 0.72 | MAPT (0.42) | PNPMAPTALDH1A1MAPK1 | |
| SCHEMBL7656354 | 0.72 | PNP (0.36) | PDCD1CD274PNP | |
| SCHEMBL7655218 | 0.72 | GRIN2D (0.39) | PDCD1CD274PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |