Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806113 | 0.88 | KDM4E (0.60) | KDM4EPOLBCISD2GAAUSP2 | |
| SCHEMBL7655424 | 0.81 | KDM4E (0.49) | KDM4EPOLBCISD2GAAUSP2 | |
| SCHEMBL7657936 | 0.78 | SMN1; SMN2 (0.46) | KDM4EPOLBMAPK1SMN1; SMN2MAPT | |
| SCHEMBL6826509 | 0.78 | KDM4E (0.56) | KDM4EPOLBCISD2GAAUSP2 | |
| SCHEMBL6943414 | 0.75 | KDM4E (0.47) | KDM4EPOLBCISD2GAAUSP2 | |
| SCHEMBL4039970 | 0.74 | MAPT (0.47) | KDM4EPOLBGAATUBB4ATUBB | |
| SCHEMBL2857865 | 0.73 | KDM4E (0.78) | KDM4EPOLBGAAUSP2HSD17B10 | |
| SCHEMBL29033634 | 0.73 | KDM4E (0.49) | KDM4EPOLBTUBB4ATUBBTUBA3C | |
| SCHEMBL1807423 | 0.73 | KDM4E (0.49) | KDM4EPOLBHSD17B10TUBB4ATUBB | |
| SCHEMBL14994071 | 0.72 | KDM4E (0.53) | KDM4EPOLBCISD2GAAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |