Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27775659 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBPKMKMT2AMEN1 | |
| SCHEMBL6948699 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBPKMKMT2AMEN1 | |
| SCHEMBL6948863 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2POLBPKMKMT2AMEN1 | |
| SCHEMBL7656050 | 0.78 | KDM4E (0.51) | SMN1; SMN2POLBKDM4EL3MBTL1MAPK1 | |
| SCHEMBL6953716 | 0.78 | PDE5A (0.44) | SMN1; SMN2POLBPKMKMT2AMEN1 | |
| SCHEMBL31451828 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBPKMKMT2AMEN1 | |
| SCHEMBL5963109 | 0.76 | PKM (0.59) | PKMKMT2AMEN1CYP3A4HTT | |
| SCHEMBL29033623 | 0.75 | PKM (0.50) | SMN1; SMN2POLBPKMKMT2AMEN1 | |
| SCHEMBL29033599 | 0.75 | KDM4E (0.54) | POLBPKMKMT2AMEN1CYP3A4 | |
| SCHEMBL17934386 | 0.73 | EGFR (0.45) | SMN1; SMN2POLBKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |