Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 8/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | CPS1 | P31327 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790235 | 0.86 | CYP2D6 (0.67) | CYP2D6HTR2ASLC6A4KCNH2HTT | |
| SCHEMBL178604 | 0.83 | CYP2D6 (0.42) | CYP2D6HTR2ASLC6A4KCNH2IDH1 | |
| SCHEMBL27751973 | 0.82 | CYP2D6 (0.45) | CYP2D6HTR2ASLC6A4KCNH2HTT | |
| SCHEMBL8241491 | 0.81 | CA12 (0.45) | CYP2D6CYP1A1CYP1A2CYP1B1CA1 | |
| SCHEMBL31063437 | 0.81 | CA12 (0.45) | CYP2D6CYP1A1CYP1A2CYP1B1CA1 | |
| Ammonia Solution, Strong SCHEMBL7990378 | 0.79 | CYP1A2 (0.42) | CYP2D6HTTCYP1A1CYP1A2CYP1B1 | |
| Hydrochloric Acid SCHEMBL28901933 | 0.79 | CYP2D6 (0.72) | CYP2D6HTR2ASLC6A4KCNH2HTT | |
| SCHEMBL23123470 | 0.78 | PDE2A (0.53) | CYP2D6HTR2ASLC6A4CYP1A1CYP1A2 | |
| SCHEMBL18119637 | 0.78 | CYP1A2 (0.41) | CYP2D6HTTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL2292153 | 0.78 | ADRA2A (0.45) | CYP2D6CYP1A1CYP1A2CYP1B1CPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883824-B2 | 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2014-11-11 | — | — | US | disclosed |
| EP-2431362-A1 | 3-(4-AMINOPHENYL)-2-FURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131669-A1 | 3-(4-AMINOPHENYL)-2-FURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 大日本住友製薬株式会社 (JP) | 2010-11-18 | — | — | WO | disclosed |