Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654404 | 0.84 | CA1 (0.40) | KMT2ACA1CA2CA7CA9 | |
| SCHEMBL7654006 | 0.81 | CA1 (0.30) | CA1CA2CA7CA9 | |
| SCHEMBL7108473 | 0.80 | — | — | |
| SCHEMBL7652946 | 0.75 | TSHR (0.38) | TACR1KMT2A | |
| SCHEMBL7107688 | 0.75 | — | — | |
| SCHEMBL4169644 | 0.74 | KMT2A (0.58) | TACR1KMT2ACA1CA2CA7 | |
| SCHEMBL7107292 | 0.74 | KMT2A (0.30) | KMT2A | |
| SCHEMBL9725029 | 0.74 | KMT2A (0.58) | TACR1KMT2ACA1CA2CA7 | |
| SCHEMBL13595511 | 0.74 | KMT2A (0.58) | TACR1KMT2ACA1CA2CA7 | |
| SCHEMBL7650161 | 0.73 | CA1 (0.35) | TACR1KMT2ACA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |