Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657987 | 0.86 | CA1 (0.39) | CA1CA2KMT2ACA7CA9 | |
| SCHEMBL7656741 | 0.84 | CSF1R (0.33) | CA1CA2CA7CA9RAB9A | |
| SCHEMBL7107292 | 0.83 | KMT2A (0.30) | KMT2A | |
| SCHEMBL7655274 | 0.78 | NPC1 (0.34) | KMT2ARAB9ANPC1POLBUSP2 | |
| SCHEMBL7662797 | 0.75 | NPC1 (0.31) | RAB9ANPC1POLB | |
| SCHEMBL7108473 | 0.75 | — | — | |
| SCHEMBL7656067 | 0.73 | TACR1 (0.36) | CA1CA2KMT2ATACR1CA7 | |
| SCHEMBL7661217 | 0.73 | KCNH2 (0.39) | CA1CA2KMT2ATACR1CA7 | |
| SCHEMBL9725029 | 0.73 | KMT2A (0.58) | CA1CA2KMT2ATACR1CA7 | |
| SCHEMBL13595511 | 0.73 | KMT2A (0.58) | CA1CA2KMT2ATACR1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |