Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485922 | 0.81 | GPR119 (0.61) | GPR119 | |
| SCHEMBL3486596 | 0.80 | GPR119 (0.72) | GPR119 | |
| SCHEMBL3486810 | 0.80 | GPR119 (0.72) | GPR119 | |
| SCHEMBL7655813 | 0.80 | GPR119 (0.61) | GPR119KDM4EMAPTTHRB | |
| SCHEMBL3486720 | 0.79 | GPR119 (0.59) | GPR119 | |
| SCHEMBL3485938 | 0.77 | GPR119 (0.74) | GPR119 | |
| SCHEMBL3486533 | 0.77 | GPR119 (0.67) | GPR119 | |
| SCHEMBL3486432 | 0.77 | GPR119 (0.67) | GPR119 | |
| SCHEMBL3486712 | 0.76 | GPR119 (0.71) | GPR119 | |
| SCHEMBL3486232 | 0.76 | GPR119 (0.68) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498161-B1 | TREATING INFECTION BY HIV; DELAYING OF THE ONSET OF AIDS; ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS OR RHEUMATOID ARTHRITIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |
| WO-2000059498-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |