SCHEMBL7656535

SCHEMBL7656535

COc1ccc(C(=O)C=Cc2ccc(Cl)cc2)c(O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 8/20 1.00
MAOB P27338 5/20 1.00
MAPT P10636 4/20 0.84
LMNA P02545 3/20 0.84
APP P05067 3/20 0.84
MEN1 O00255 3/20 0.84
MAPK1 P28482 3/20 0.84
KMT2A Q03164 3/20 0.84
CYP3A4 P08684 2/20 0.84
SMN1; SMN2 Q16637 2/20 0.84
CYP2C19 P33261 1/20 0.84
CTSL P07711 1/20 0.76
ALDH1A1 P00352 2/20 0.76
HPGD P15428 2/20 0.76
ALOX15 P16050 2/20 0.76
HSD17B10 Q99714 2/20 0.76
NPC1 O15118 1/20 0.76
RECQL P46063 1/20 0.76
RAB9A P51151 1/20 0.76
ATM Q13315 1/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25198168 1.00 ABCG2 (1.00) ABCG2MAOBMAPTLMNAAPP
SCHEMBL25188859 0.93 ABCG2 (0.97) ABCG2MAOBMAPTLMNAAPP
SCHEMBL25197992 0.92 MAOB (0.85) ABCG2MAOBMAPTLMNAAPP
SCHEMBL25195950 0.92 MAOB (0.85) ABCG2MAOBMAPTLMNAAPP
SCHEMBL634186 0.92 ABCG2 (1.00) ABCG2MAOBMAPTLMNAAPP
SCHEMBL30382670 0.92 ABCG2 (1.00) ABCG2MAOBMAPTLMNAAPP
SCHEMBL25189208 0.92 ABCG2 (1.00) ABCG2MAOBMAPTLMNAAPP
SCHEMBL30384538 0.92 ABCG2 (1.00) ABCG2MAOBMAPTLMNAAPP
SCHEMBL634187 0.92 ABCG2 (1.00) ABCG2MAOBMAPTLMNAAPP
SCHEMBL5515061 0.90 ABCG2 (0.91) ABCG2MAOBMAPTLMNAAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4531824-A1 CHALCONE DERIVATIVES, MODULATOR OF FIBROBLASTS, FOR USE IN THE TREATMENT OF STROMA-RICH TUMORS Universiteit Gent (BE) 2025-04-09 EP disclosed
CN-119451668-A Chalcone derivatives and modulators of fibroblasts for the treatment of stromal rich tumors 根特大学 2025-02-14 CN disclosed
CN-117624162-A Flavonol derivative containing triazolopyridine and preparation method and application thereof 贵州大学 2024-03-01 CN disclosed
WO-2023232866-A1 CHALCONE DERIVATIVES, MODULATOR OF FIBROBLASTS, FOR USE IN THE TREATMENT OF STROMA-RICH TUMORS UNIVERSITEIT GENT (BE) 2023-12-07 WO disclosed
US-6500846-B1 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE LG CHEMICAL, LTD. (KR) 2002-12-31 US disclosed
EP-1109800-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LIMITED (KR) 2001-06-27 EP disclosed
WO-2000012496-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LTD. (KR) 2000-03-09 WO disclosed