SCHEMBL25197992

SCHEMBL25197992

COc1ccc(/C=C/C(=O)c2ccc(Cl)cc2O)cc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.85
ABCG2 Q9UNQ0 6/20 0.85
MAPT P10636 4/20 0.80
LMNA P02545 3/20 0.80
APP P05067 3/20 0.80
MEN1 O00255 2/20 0.80
CYP3A4 P08684 2/20 0.80
MAPK1 P28482 2/20 0.80
KMT2A Q03164 2/20 0.80
CYP2C19 P33261 2/20 0.80
SMN1; SMN2 Q16637 1/20 0.80
ALDH1A1 P00352 1/20 0.76
TP53 P04637 1/20 0.76
HPGD P15428 1/20 0.76
ALOX15 P16050 1/20 0.76
HSD17B10 Q99714 1/20 0.76
ACHE P22303 1/20 0.71
BACE1 P56817 1/20 0.71
MAOA P21397 5/20 0.69
CTSL P07711 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25195950 1.00 MAOB (0.85) MAOBABCG2MAPTLMNAAPP
SCHEMBL7656535 0.92 ABCG2 (1.00) MAOBABCG2MAPTLMNAAPP
SCHEMBL25198168 0.92 ABCG2 (1.00) MAOBABCG2MAPTLMNAAPP
SCHEMBL14692635 0.89 MAOB (0.83) MAOBABCG2MAPTMEN1MAPK1
SCHEMBL10829683 0.89 MAOB (0.83) MAOBABCG2MAPTMEN1MAPK1
SCHEMBL25189208 0.89 ABCG2 (1.00) MAOBABCG2MAPTLMNAAPP
SCHEMBL634187 0.89 ABCG2 (1.00) MAOBABCG2MAPTLMNAAPP
SCHEMBL634186 0.89 ABCG2 (1.00) MAOBABCG2MAPTLMNAAPP
SCHEMBL30382670 0.89 ABCG2 (1.00) MAOBABCG2MAPTLMNAAPP
SCHEMBL30384538 0.89 ABCG2 (1.00) MAOBABCG2MAPTLMNAAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885ABCG2 1606/4885MAPT 3297/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885ABCG2 3622/4885MAPT 3512/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885ABCG2 3622/4885MAPT 3512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.