Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 5/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764428 | 0.90 | BDKRB1 (0.51) | BDKRB1MAPK14CYP3A4VNN1CTSL | |
| SCHEMBL764449 | 0.90 | BDKRB1 (0.49) | BDKRB1MAPK14CYP3A4PTGDR2PTGER4 | |
| SCHEMBL764480 | 0.90 | BDKRB1 (0.53) | BDKRB1MAPK14CYP3A4VNN1KDM1A | |
| SCHEMBL765805 | 0.90 | BDKRB1 (0.49) | BDKRB1MAPK14CYP3A4CTSLPTGDR2 | |
| SCHEMBL765846 | 0.90 | BDKRB1 (0.49) | BDKRB1MAPK14CYP3A4UCHL1VNN1 | |
| SCHEMBL765845 | 0.88 | MAPK14 (0.58) | BDKRB1MAPK14CYP3A4UCHL1CTSL | |
| SCHEMBL765145 | 0.87 | BDKRB1 (0.48) | BDKRB1MAPK14CYP3A4KDM1AHDAC1 | |
| SCHEMBL13904099 | 0.87 | BDKRB1 (0.51) | BDKRB1MAPK14CYP3A4KDM1AHDAC1 | |
| SCHEMBL13904097 | 0.84 | BDKRB1 (0.49) | BDKRB1MAPK14CYP3A4KDM1AHDAC1 | |
| SCHEMBL765204 | 0.81 | BDKRB1 (0.51) | BDKRB1MAPK14CYP3A4PTGER4PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |