Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13842699 | 0.84 | KDM4E (0.63) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL3266075 | 0.84 | TP53 (0.56) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL9891512 | 0.80 | TP53 (0.59) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL9892890 | 0.80 | HTT (0.60) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL20458204 | 0.77 | KDM4E (0.56) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL6434931 | 0.76 | KDM4E (0.64) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL9892932 | 0.75 | KDM4E (0.53) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL3711268 | 0.75 | ADORA3 (0.55) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL15031108 | 0.73 | KDM4E (0.51) | KDM4ETP53HSD17B10HTTALDH1A1 | |
| SCHEMBL16253075 | 0.71 | KDM4E (0.49) | KDM4ETP53HSD17B10HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340696-B1 | ADMINISTERING THERAPEUTICALLY EFFECTIVE AMOUNT OF COMBINATION OF (5-ARYL-1,2,4-THIADIAZOL)-3-YL THIOUREA DERIVATIVE OR (5-ARYL-1,2,4-THIADIAZOL)-3-YL UREA DERIVATIVE AND RIBAVIRIN AND/OR INTERFERON | THE PROCTER & GAMBLE COMPANY | 2002-01-22 | — | — | US | disclosed |