Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655781 | 0.88 | NSD2 (0.44) | NSD2CASP6SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7654647 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2ANOX1 | |
| SCHEMBL7650131 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL7655830 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2ANOX1 | |
| SCHEMBL7655919 | 0.79 | FERMT2 (0.52) | SMN1; SMN2NOX1MAPTHTTGAA | |
| SCHEMBL7655772 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MEN1KMT2ANOX1 | |
| Bromide SCHEMBL7657001 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2ANOX1 | |
| SCHEMBL23182885 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL11246752 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MEN1KMT2ANOX1 | |
| SCHEMBL18622660 | 0.75 | FERMT2 (0.50) | SMN1; SMN2ALDH1A1CYP1A2CYP2D6NOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |