Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649581 | 0.96 | CNR2 (0.56) | CNR2KDM4ESMN1; SMN2KMT2ATP53 | |
| SCHEMBL7650022 | 0.81 | TNF (0.73) | CNR2TP53TNF | |
| SCHEMBL7656518 | 0.81 | TNF (0.67) | CNR2KDM4ETP53TNF | |
| SCHEMBL7649598 | 0.78 | TSHR (0.55) | CNR2KDM4ESMN1; SMN2KMT2ATNF | |
| SCHEMBL7653389 | 0.78 | P2RX4 (0.60) | SMN1; SMN2KMT2ATP53MAPT | |
| SCHEMBL25936310 | 0.77 | KDM4E (0.61) | CNR2KDM4ESMN1; SMN2KMT2ATP53 | |
| SCHEMBL7650027 | 0.77 | TNF (0.68) | CNR2KDM4EKMT2ATNF | |
| SCHEMBL7652923 | 0.77 | P2RX4 (0.58) | SMN1; SMN2KMT2ATP53MAPT | |
| SCHEMBL7652144 | 0.76 | BCHE (0.51) | CNR2KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5037066 | 0.75 | TNF (0.59) | CNR2KDM4ESMN1; SMN2KMT2ATNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |