Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | METAP1 | P53582 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6374844 | 0.96 | RAB9A (0.66) | RAB9ANPC1METAP1MAPTKMT2A | |
| SCHEMBL20187714 | 0.88 | HPGD (0.59) | RAB9ANPC1MAPTKMT2AALDH1A1 | |
| SCHEMBL28242074 | 0.87 | HPGD (0.61) | RAB9ANPC1MAPTKMT2AALDH1A1 | |
| SCHEMBL3898465 | 0.84 | HPGD (0.61) | RAB9ANPC1MAPTKMT2AALDH1A1 | |
| SCHEMBL20188098 | 0.84 | HPGD (0.65) | RAB9ANPC1METAP1MAPTKMT2A | |
| SCHEMBL22015905 | 0.84 | HPGD (0.65) | RAB9ANPC1METAP1MAPTKMT2A | |
| SCHEMBL6498262 | 0.82 | MAPT (0.54) | RAB9ANPC1METAP1MAPTKMT2A | |
| SCHEMBL6374746 | 0.82 | KDM4E (0.71) | RAB9ANPC1METAP1MAPTKMT2A | |
| SCHEMBL3900474 | 0.82 | SIRT2 (0.60) | RAB9ANPC1MAPTKMT2AALDH1A1 | |
| SCHEMBL7958507 | 0.81 | HPGD (0.55) | METAP1MAPTKMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |