Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21085193 | 0.84 | FNTA (0.58) | CES2CES1AKR1B1RENALOX5 | |
| SCHEMBL7657322 | 0.83 | KMT2A (0.53) | RENMEN1KMT2AALOX5HDAC3 | |
| SCHEMBL673384 | 0.83 | HDAC6 (0.63) | HSD17B10HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5232476 | 0.83 | SRD5A2 (0.51) | SRD5A2NR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL8012661 | 0.82 | CES1 (0.45) | CES2CES1AKR1B1RENMEN1 | |
| SCHEMBL7656457 | 0.81 | HDAC6 (0.60) | TSHRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7650749 | 0.81 | HPGD (0.58) | MEN1KMT2AHDAC1HDAC6MAPT | |
| SCHEMBL7655904 | 0.81 | SMN1; SMN2 (0.58) | MEN1KMT2AMAPTL3MBTL1TP53 | |
| SCHEMBL8012822 | 0.79 | CES1 (0.45) | CES2CES1AKR1B1RENMEN1 | |
| SCHEMBL6929677 | 0.78 | MAPT (0.45) | NR4A2AKR1B1RENHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-1033366-A2 | Amide derivatives useful as Neuropeptide Y (NPY) antagonists | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |