SCHEMBL7657322

SCHEMBL7657322

CN(C)C(=O)c1ccc(N(C(=O)Cc2ccccc2)C(=O)Cc2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.53
MEN1 O00255 1/20 0.53
PDK1 Q15118 3/20 0.48
PDK2 Q15119 2/20 0.48
PDK4 Q16654 2/20 0.48
PDK3 Q15120 1/20 0.48
REN P00797 1/20 0.44
NR1H4 Q96RI1 2/20 0.44
ALDH1A1 P00352 2/20 0.43
MAPT P10636 1/20 0.43
HPGD P15428 1/20 0.43
TRPM8 Q7Z2W7 1/20 0.43
CNR2 P34972 1/20 0.43
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7650749 0.85 HPGD (0.58) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL7657647 0.83 SRD5A2 (0.54) KMT2AMEN1RENMAPTHDAC3
SCHEMBL7655904 0.79 SMN1; SMN2 (0.58) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL21085193 0.78 FNTA (0.58) RENALDH1A1MAPK1ALOX5
SCHEMBL673384 0.78 HDAC6 (0.63) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8013112 0.77 REN (0.43) KMT2AMEN1RENNR1H4TRPM8
SCHEMBL8012661 0.77 CES1 (0.45) KMT2AMEN1RENTRPM8CNR2
SCHEMBL7656457 0.76 HDAC6 (0.60) NR1H4ALDH1A1HPGDHDAC3HDAC4
SCHEMBL339507 0.75 CES2 (0.56) KMT2AMEN1RENTRPM8HDAC8
SCHEMBL17653897 0.74 NR1H4 (0.58) NR1H4ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407120-B1 ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS PFIZER INC. 2002-06-18 US disclosed
EP-1033366-A2 Amide derivatives useful as Neuropeptide Y (NPY) antagonists Pfizer Products Inc. (US) 2000-09-06 EP disclosed