Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837818 | 0.94 | EGLN1 (0.36) | CHEK1EGLN1IGF1RSRD5A2MMP13 | |
| Acetic Acid SCHEMBL7658238 | 0.90 | EGLN1 (0.40) | CHEK1EGLN1IGF1REGFRFLT4 | |
| Acetic Acid SCHEMBL7657890 | 0.90 | CHEK1 (0.39) | CHEK1EGLN1IGF1REGFRFLT4 | |
| Acetic Acid SCHEMBL7657826 | 0.89 | CHEK1 (0.39) | CHEK1EGLN1IGF1REGFRFLT4 | |
| SCHEMBL7656458 | 0.89 | PDE4B (0.40) | KDRPDE4BPDE4D | |
| Acetic Acid SCHEMBL7661589 | 0.88 | IP6K1 (0.42) | CHEK1EGLN1IGF1REGFRFLT4 | |
| Acetic Acid SCHEMBL7817644 | 0.88 | EGLN1 (0.40) | CHEK1EGLN1IGF1REGFRFLT4 | |
| Acetic Acid SCHEMBL7815908 | 0.88 | CAMK2D (0.39) | CHEK1EGLN1IGF1REGFRFLT4 | |
| SCHEMBL7661596 | 0.87 | IGF1R (0.35) | CHEK1EGLN1IGF1REGFRFLT4 | |
| Acetic Acid SCHEMBL7655888 | 0.87 | EGLN1 (0.38) | CHEK1EGLN1IGF1REGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |
| EP-1071683-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999046264-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |