Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | TP53 | P04637 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | CASP1 | P29466 | 5/20 | 0.64 |
| ▸ | CASP7 | P55210 | 5/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7660020 | 0.91 | MAPT (0.70) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL7666088 | 0.82 | MAPT (0.72) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL7656073 | 0.82 | MAPT (0.72) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL7656375 | 0.82 | MEN1 (0.62) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL19721025 | 0.78 | MEN1 (1.00) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL30667460 | 0.78 | MEN1 (1.00) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL925722 | 0.78 | MAPT (0.72) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL7651981 | 0.78 | MAPT (0.72) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL7655740 | 0.78 | KDM4E (0.72) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL7660093 | 0.77 | CYP3A4 (0.83) | MAPTKDM4ETP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500846-B1 | 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE | LG CHEMICAL, LTD. (KR) | 2002-12-31 | — | — | US | disclosed |