Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10121524 | 0.93 | BDKRB1 (0.44) | BDKRB1LMNAHTTSMN1; SMN2KDM1A | |
| SCHEMBL10121214 | 0.92 | BDKRB1 (0.40) | BDKRB1MAPK14KDM1AHDAC1DDR2 | |
| SCHEMBL765844 | 0.89 | BDKRB1 (0.42) | BDKRB1MAPK14DDR2SCDPTGER4 | |
| SCHEMBL765198 | 0.84 | BDKRB1 (0.42) | BDKRB1KDM1AHDAC1 | |
| SCHEMBL765544 | 0.84 | BDKRB1 (0.42) | BDKRB1KDM1AHDAC1 | |
| SCHEMBL756525 | 0.84 | BDKRB1 (0.42) | BDKRB1KDM1AHDAC1 | |
| SCHEMBL757814 | 0.84 | BDKRB1 (0.42) | BDKRB1KDM1AHDAC1 | |
| SCHEMBL764481 | 0.84 | BDKRB1 (0.42) | BDKRB1SMN1; SMN2KDM1AHDAC1DDR1 | |
| SCHEMBL10121111 | 0.82 | BDKRB1 (0.37) | BDKRB1HTTMAPK14PTGER4PTGER2 | |
| SCHEMBL765643 | 0.82 | BDKRB1 (0.45) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |