SCHEMBL7658685

SCHEMBL7658685

CN(C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N)[C@@H](COCCO)Cc1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 8/20 0.63
OPRM1 P35372 2/20 0.33
MAOB P27338 1/20 0.33
PPARG P37231 1/20 0.33
PPARD Q03181 1/20 0.33
PPARA Q07869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7658691 1.00 GHSR (0.63) GHSROPRM1MAOBPPARGPPARD
SCHEMBL6320645 0.85 GHSR (0.66) GHSR
SCHEMBL6320638 0.85 GHSR (0.66) GHSR
SCHEMBL6325612 0.85 GHSR (0.66) GHSR
SCHEMBL6322878 0.85 GHSR (0.54) GHSRMAOB
SCHEMBL6322881 0.85 GHSR (0.54) GHSRMAOB
SCHEMBL18472634 0.84 GHSR (0.65) GHSR
SCHEMBL8906613 0.84 GHSR (0.59) GHSROPRM1
SCHEMBL7122761 0.84 GHSR (0.59) GHSROPRM1
SCHEMBL6327147 0.84 GHSR (0.59) GHSROPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US claimed
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US disclosed
US-6013658-A ANIMAL GROWTH REGULATORS NOVO NORDISK A/S (DK) 2000-01-11 US disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 WO disclosed