SCHEMBL7658700

SCHEMBL7658700

NC(=O)c1ccc(NC(=S)Nc2ccc(F)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.67
L3MBTL1 Q9Y468 1/20 0.67
MEN1 O00255 3/20 0.64
KMT2A Q03164 3/20 0.64
POLB P06746 2/20 0.64
GAA P10253 3/20 0.59
IDO1 P14902 1/20 0.59
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58
CA4 P22748 1/20 0.58
CA9 Q16790 1/20 0.58
KDM4E B2RXH2 2/20 0.58
MAPT P10636 2/20 0.58
LMNA P02545 2/20 0.58
MAPK1 P28482 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
PPARG P37231 1/20 0.56
NCOA2 Q15596 1/20 0.56
NCOA1 Q15788 1/20 0.56
RXFP1 Q9HBX9 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7657194 0.85 ALDH1A1 (0.66) ALDH1A1L3MBTL1MEN1KMT2AGAA
SCHEMBL6815438 0.84 MAPT (0.64) ALDH1A1L3MBTL1MEN1KMT2APOLB
SCHEMBL3076566 0.84 PTPN1 (0.73) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL6815731 0.84 ALDH1A1 (0.73) ALDH1A1L3MBTL1MEN1KMT2APOLB
SCHEMBL27583806 0.84 PTPN1 (0.73) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL6811354 0.83 KMT2A (0.62) ALDH1A1L3MBTL1MEN1KMT2APOLB
SCHEMBL6816535 0.83 MAPT (0.77) ALDH1A1L3MBTL1MEN1KMT2APOLB
Thiourea SCHEMBL28414185 0.82 PARP10 (0.55) ALDH1A1L3MBTL1KMT2APOLBCA1
SCHEMBL10099725 0.82 GAA (0.83) ALDH1A1L3MBTL1MEN1KMT2APOLB
SCHEMBL6811493 0.82 ALDH1A1 (0.67) ALDH1A1L3MBTL1MEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407249-B1 COMPOUNDS CONTAINING FURAN RING STRUCTURE AMERICAN HOME PRODUCTS CORPORATION 2002-06-18 US disclosed
US-6335350-B1 VARICELLA-ZOSTER, HUMAN CYTOMEGALO, EPSTEIN-BARR AND KAPOSI HERPESVIRUS TREATMENT AMERICAN HOME PRODUCTS CORPORATION 2002-01-01 US disclosed
US-6207715-B1 USEFUL IN THERAPY OF DISEASES ASSOCIATED WITH HERPES VIRUSES INCLUDING HUMAN CYTOMEGALOVIRUS, HERPES SIMPLEX VIRUSES, EPSTEIN-BARR VIRUS, VARICELLA-ZOSTER VIRUS, HUMAN HERPESVIRUSES-6 AND -7, AND KAPOSI HERPES VIRUS AMERICAN HOME PRODUCTS CORPORATION 2001-03-27 US disclosed
US-6201013-B1 INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) INHIBITOR; SIDE EFFECT REDUCTION, NON-DRUG RESISTANT AMERICAN HOME PRODUCTS CORPORATION 2001-03-13 US disclosed
US-6166028-A Diaminopuridine-containing thiourea inhibitors of herpes viruses AMERICAN HOME PRODUCTS CORPORATION (US) 2000-12-26 US disclosed