Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.62 |
| ▸ | PLG | P00747 | 2/20 | 0.62 |
| ▸ | PLAU | P00749 | 2/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299433 | 0.89 | F2 (0.48) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL7653743 | 0.83 | MAPT (0.47) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL7661476 | 0.78 | MAPT (0.48) | MAPTKDM4EMEN1CYP2D6CYP2C9 | |
| SCHEMBL6298345 | 0.77 | ROCK2 (0.61) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL7660377 | 0.77 | MAPT (0.52) | MAPTKDM4EMEN1CYP2D6CYP2C9 | |
| SCHEMBL7658503 | 0.76 | MAPT (0.47) | MAPTKDM4EMEN1CYP2D6CYP2C9 | |
| SCHEMBL6293579 | 0.74 | ROCK2 (0.53) | MAPTKDM4EMEN1CYP2D6CYP2C9 | |
| SCHEMBL7012602 | 0.74 | MAPT (0.49) | MAPTKDM4EMEN1CYP2D6CYP2C9 | |
| SCHEMBL7652942 | 0.74 | MAPT (0.47) | MAPTKDM4EMEN1CYP2D6CYP2C9 | |
| SCHEMBL7013060 | 0.74 | MAPT (0.49) | MAPTKDM4EMEN1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | disclosed |