Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382515 | 0.85 | HTT (0.51) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL18787387 | 0.84 | HPGD (0.50) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL7459054 | 0.83 | FDFT1 (0.49) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL382562 | 0.82 | HTT (0.48) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL7051580 | 0.81 | HPGD (0.50) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL21135465 | 0.80 | HPGD (0.49) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL16479353 | 0.80 | HTT (0.55) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL1096771 | 0.78 | TDP1 (0.55) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL7470844 | 0.78 | ALDH1A1 (0.50) | HTTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL11381594 | 0.78 | HTT (0.59) | HTTHPGDALDH1A1TDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |