Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3335156 | 0.73 | MAPT (0.48) | KDM4EMAPTALDH1A1PTK2BSMN1; SMN2 | |
| SCHEMBL25757649 | 0.73 | MAPT (0.48) | KDM4EMAPTLMNABLMHTT | |
| SCHEMBL2296665 | 0.70 | MAPT (0.44) | KDM4EMAPTALDH1A1PTK2BSMN1; SMN2 | |
| SCHEMBL13859959 | 0.69 | MAPT (0.71) | KDM4EMAPTALDH1A1POLBLMNA | |
| SCHEMBL5773101 | 0.69 | GSK3B (0.51) | KDM4EMAPTLMNABLMHTT | |
| SCHEMBL12210337 | 0.69 | TDP1 (0.45) | KDM4EALDH1A1SMN1; SMN2GAABLM | |
| SCHEMBL217044 | 0.69 | MAPT (1.00) | KDM4EMAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6872589 | 0.68 | KDM4E (0.36) | KDM4EMAPTALDH1A1PTK2BSMN1; SMN2 | |
| SCHEMBL6610170 | 0.68 | SMN1; SMN2 (0.48) | KDM4EMAPTALDH1A1PTK2BSMN1; SMN2 | |
| SCHEMBL6610179 | 0.68 | SMN1; SMN2 (0.48) | KDM4EMAPTALDH1A1PTK2BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498176-B1 | INHIBITING TUMOR GROWTH VIA INHIBITION OF TUMOR-RELATED ANGIOGENESIS | SMITHKLINEBEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |