Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610170 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2RETFLT3MAPTNTRK1 | |
| SCHEMBL3335156 | 0.77 | MAPT (0.48) | SMN1; SMN2MAPTMEN1KMT2ACHEK1 | |
| SCHEMBL5432754 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2RETFLT3MAPTNTRK1 | |
| SCHEMBL5432755 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2RETFLT3MAPTNTRK1 | |
| SCHEMBL6613240 | 0.76 | LIPG (0.36) | RETFLT3MAPTNTRK1NTRK3 | |
| SCHEMBL6613242 | 0.76 | LIPG (0.36) | RETFLT3MAPTNTRK1NTRK3 | |
| SCHEMBL5893585 | 0.75 | SMN1; SMN2 (0.59) | SMN1; SMN2RETMAPTNTRK1NTRK3 | |
| SCHEMBL5873941 | 0.75 | SMN1; SMN2 (0.59) | SMN1; SMN2RETMAPTNTRK1NTRK3 | |
| SCHEMBL6613736 | 0.74 | TGM2 (0.32) | SMN1; SMN2RETFLT3MAPTNTRK1 | |
| SCHEMBL6610327 | 0.74 | CHEK1 (0.32) | SMN1; SMN2RETFLT3MAPTNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313732-B1 | OXINDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-11-03 | — | — | EP | disclosed |
| US-6720332-B2 | Oxindole derivatives | SMITHKLINE BEECHAM CORPORATION | 2004-04-13 | — | — | US | disclosed |
| US-20030195189-A1 | Oxindole derivatives | SMITHKLINE BEECHAM CORPORATION | 2003-10-16 | — | — | US | disclosed |
| EP-1313732-A1 | OXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002020524-A1 | OXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2002-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195189-A1 | Oxindole derivatives | CDK4, CCNI, CCNO | SMN1; SMN2 4091/4885RET 527/4885FLT3 938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.