Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662082 | 0.90 | SMN1; SMN2 (0.71) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL22691765 | 0.85 | SMN1; SMN2 (0.53) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL28860065 | 0.84 | NPC1 (0.54) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL3070804 | 0.82 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL8684761 | 0.82 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL1455603 | 0.81 | POLB (0.53) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL7271233 | 0.80 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL7271237 | 0.80 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL20809605 | 0.79 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL27683910 | 0.79 | SMN1; SMN2 (0.55) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101166733-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2008-04-23 | — | — | CN | claimed |
| CN-111886233-B | Triazolone derivatives or salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2024-01-02 | — | — | CN | disclosed |
| CN-116437913-A | Pharmaceutical compounds for treating complement-mediated disorders | 艾其林医药公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-115433160-B | Analgesic active compounds and medical application thereof | 中国人民解放军军事科学院军事医学研究院 | 2023-06-30 | — | — | CN | disclosed |
| CN-115433160-A | Analgesic active compound and medical application thereof | 中国人民解放军军事科学院军事医学研究院 | 2022-12-06 | — | — | CN | disclosed |
| CN-111886233-A | Novel triazolone derivative or salt thereof and pharmaceutical composition comprising the same | 柳韩洋行 | 2020-11-03 | — | — | CN | disclosed |
| CN-107108591-B | Resorcinol derivatives as HSP90 inhibitors | 正大天晴药业集团股份有限公司 | 2020-05-05 | — | — | CN | disclosed |
| CN-101166733-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2008-04-23 | — | — | CN | disclosed |
| CN-1589153-A | Prevention or treatment of urinary disorders | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-03-02 | — | — | CN | disclosed |
| US-6462076-B2 | CYSTEINE PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CYSTEINE PROTEASES, SUCH AS OSTEOPOROSIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, TUMOR METASTASIS, ANGINA PECTORIS, PLAQUE RUPTURE AND STROKE ETC. | HOFFMANN-LA ROCHE INC. | 2002-10-08 | — | — | US | disclosed |