Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004747 | 0.94 | ALPL (0.46) | PARP1ALPLPOLBDAORAB9A | |
| SCHEMBL30939057 | 0.90 | ALPL (0.44) | ALPLPOLBDAORAB9ANPC1 | |
| SCHEMBL17279708 | 0.87 | ALPL (0.53) | ALPLPOLBDAORAB9ANPC1 | |
| SCHEMBL4771122 | 0.81 | MAPT (0.41) | PARP1RAB9ANPC1 | |
| SCHEMBL6004530 | 0.79 | MAPT (0.41) | PARP1RAB9ANPC1 | |
| SCHEMBL26107571 | 0.79 | MAPT (0.41) | PARP1RAB9ANPC1 | |
| SCHEMBL26111895 | 0.78 | ALPL (0.51) | ALPLPOLBDAORAB9ANPC1 | |
| SCHEMBL26110996 | 0.78 | MAPT (0.50) | — | |
| SCHEMBL21634176 | 0.78 | NR1H2 (0.46) | ALPLPOLBDAORAB9ANPC1 | |
| SCHEMBL26112168 | 0.78 | NR1H2 (0.54) | ALPLPOLBDAORAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |