Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL819239 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9APREPCYP2C19 | |
| SCHEMBL23485195 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9APREPCYP2C19 | |
| SCHEMBL820285 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9APREPCYP2C19 | |
| SCHEMBL8728752 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9APREPCYP2C19 | |
| SCHEMBL21874110 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9ACYP2C19ELANE | |
| SCHEMBL5740609 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APREPCYP2C19 | |
| SCHEMBL29302842 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APREPCYP2C19 | |
| SCHEMBL29302825 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APREPCYP2C19 | |
| SCHEMBL14371889 | 0.82 | KLK7 (0.48) | SMN1; SMN2NPC1RAB9AALDH1A1ELANE | |
| SCHEMBL820518 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9APREPCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237862-A1 | SUCCINATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION | Versicor, Inc. (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044179-A1 | NOVEL SUCCINATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION | VERSICOR, INC. (US) | 2001-06-21 | — | — | WO | disclosed |