Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 14/20 | 0.58 |
| ▸ | GAK | O14976 | 3/20 | 0.58 |
| ▸ | FBP1 | P09467 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.53 |
| ▸ | BUB1 | O43683 | 2/20 | 0.53 |
| ▸ | STK10 | O94804 | 2/20 | 0.53 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.53 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014899 | 0.80 | EGFR (0.66) | KDREGFRGAKFBP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7016965 | 0.79 | EGFR (0.64) | KDREGFRGAKFBP1ALDH1A1 | |
| SCHEMBL30804558 | 0.78 | EGFR (0.65) | KDREGFRGAKFBP1ALDH1A1 | |
| SCHEMBL1507534 | 0.78 | EGFR (0.65) | KDREGFRGAKFBP1ALDH1A1 | |
| SCHEMBL7019299 | 0.77 | EGFR (0.51) | KDREGFRGAKFBP1ALDH1A1 | |
| SCHEMBL29894409 | 0.76 | ABCG2 (0.76) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL183355 | 0.76 | ABCG2 (0.76) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507464 | 0.76 | EGFR (0.70) | KDREGFRGAKFBP1ALDH1A1 | |
| SCHEMBL1507562 | 0.76 | EGFR (0.67) | KDREGFRGAKFBP1ALDH1A1 | |
| SCHEMBL7542136 | 0.74 | AURKA (0.55) | KDREGFRGAKFBP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395733-B1 | ANTICANCER AGENTS; ANTIPROLIFERATIVE AGENTS | PFIZER INC | 2002-05-28 | — | — | US | disclosed |