Sugi Predict

Sugi Predict / Compounds / SCHEMBL183355

SCHEMBL183355

SCHEMBL183355

C#Cc1cccc(Nc2ncnc3ccccc23)c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCG2 Q9UNQ0 6/20 0.76
▸ EGFR P00533 14/20 0.66
▸ FBP1 P09467 2/20 0.66
▸ GAK O14976 2/20 0.66
▸ ALDH1A1 P00352 1/20 0.66
▸ MAPT P10636 1/20 0.66
▸ HTT P42858 2/20 0.64
▸ FADS1 O60427 1/20 0.64
▸ AHR P35869 1/20 0.64
▸ GLA P06280 1/20 0.64
▸ DAPK3 O43293 1/20 0.63
▸ MAP4K4 O95819 1/20 0.63
▸ ABL1 P00519 1/20 0.63
▸ ERBB2 P04626 1/20 0.63
▸ PIM1 P11309 1/20 0.63
▸ PRKACA P17612 1/20 0.63
▸ LTK P29376 1/20 0.63
▸ MAPK8 P45983 1/20 0.63
▸ CSNK1A1 P48729 1/20 0.63
▸ RPS6KA3 P51812 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29894409 1.00 ABCG2 (0.76) ABCG2EGFRFBP1GAKALDH1A1
SCHEMBL1507562 0.85 EGFR (0.67) ABCG2EGFRFBP1GAKALDH1A1
SCHEMBL27511964 0.85 EGFR (0.69) ABCG2EGFRFBP1GAKALDH1A1
SCHEMBL1507464 0.85 EGFR (0.70) ABCG2EGFRFBP1GAKALDH1A1
SCHEMBL4356364 0.85 EGFR (0.69) ABCG2EGFRFBP1GAKALDH1A1
Hydrochloric Acid SCHEMBL9017046 0.85 ABCG2 (0.97) ABCG2EGFRHTTFADS1AHR
SCHEMBL7976867 0.85 EGFR (0.70) ABCG2EGFRFBP1GAKALDH1A1
SCHEMBL23934778 0.84 EGFR (0.67) ABCG2EGFRFBP1GAKALDH1A1
Hydrochloric Acid SCHEMBL7665701 0.84 EGFR (0.67) ABCG2EGFRFBP1GAKALDH1A1
Hydrochloric Acid SCHEMBL7537017 0.84 EGFR (0.67) ABCG2EGFRFBP1GAKALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113200927-B Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine 上海橡实化学有限公司 2022-08-26 — — CN claimed
CN-113200927-A Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine 上海橡实化学有限公司 2021-08-03 — — CN claimed
US-20230287217-A1 Zwitterionic Cell-Permeant and Water-Soluble Rhodamine Dyes for Quantitative Imaging Applications OREGON HEALTH & SCIENCE UNIVERSITY 2023-09-14 — — US disclosed
US-20230287217-A1 Zwitterionic Cell-Permeant and Water-Soluble Rhodamine Dyes for Quantitative Imaging Applications OREGON HEALTH & SCIENCE UNIVERSITY 2023-09-14 — — US disclosed
US-20230287217-A1 Zwitterionic Cell-Permeant and Water-Soluble Rhodamine Dyes for Quantitative Imaging Applications OREGON HEALTH & SCIENCE UNIVERSITY 2023-09-14 — — US disclosed
EP-4225122-A1 ZWITTERIONIC CELL-PERMEANT AND WATER-SOLUBLE RHODAMINE DYES FOR QUANTITATIVE IMAGING APPLICATIONS Oregon Health & Science University (US) 2023-08-16 — — EP disclosed
CN-113200927-B Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine 上海橡实化学有限公司 2022-08-26 — — CN disclosed
CN-113200927-B Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine 上海橡实化学有限公司 2022-08-26 — — CN disclosed
CN-113200927-B Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine 上海橡实化学有限公司 2022-08-26 — — CN disclosed
CN-113200927-A Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine 上海橡实化学有限公司 2021-08-03 — — CN disclosed
CN-113200927-A Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine 上海橡实化学有限公司 2021-08-03 — — CN disclosed
US-20110065734-A1 NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES 4SC AG (DE) 2011-03-17 — — US disclosed
US-20110065734-A1 NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES 4SC AG (DE) 2011-03-17 — — US disclosed
US-20110065734-A1 NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES 4SC AG (DE) 2011-03-17 — — US disclosed
EP-2271941-A2 METHODS FOR THE IDENTIFICATION OF AGENTS THAT INHIBIT MESENCHYMAL-LIKE TUMOR CELLS OR THEIR FORMATION OSI Pharmaceuticals, Inc. (US) 2011-01-12 — — EP disclosed
JP-2009161477-A TUMOR-IMAGING AGENT YOKOHAMA CITY UNIV 2009-07-23 — — JP disclosed
WO-2009063054-A1 NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES 4SC AG (DE) 2009-05-22 — — WO disclosed
EP-2060565-A1 Novel bifunctional compounds which inhibit protein kinases and histone deacetylases 4SC AG (DE) 2009-05-20 — — EP disclosed
EP-2060565-A1 Novel bifunctional compounds which inhibit protein kinases and histone deacetylases 4SC AG (DE) 2009-05-20 — — EP disclosed
CN-1137037-A Quinazoline derivatives PFIZER (US) 1996-12-04 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110065734-A1 NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES HDAC1, HDAC11, MAP2K2 ABCG2 3562/4885EGFR 1304/4885FBP1 1217/4885
US-20230287217-A1 Zwitterionic Cell-Permeant and Water-Soluble Rhodamine Dyes for Quantitative Imaging Applications SLC1A5, SLCO1B1, SLCO2B1 ABCG2 24/4885EGFR 1711/4885FBP1 3361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.