Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 3/20 | 0.59 |
| ▸ | PGK2 | P07205 | 3/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 15/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 5/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.51 |
| ▸ | PTPRB | P23467 | 3/20 | 0.50 |
| ▸ | PTPRC | P08575 | 3/20 | 0.50 |
| ▸ | CDC25A | P30304 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591720 | 0.99 | PGK1 (0.57) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL7179735 | 0.89 | PTPN1 (0.56) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL7660736 | 0.87 | PGK1 (0.67) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL7591715 | 0.85 | PGK1 (0.64) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL7183073 | 0.85 | PGK1 (0.40) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL4316972 | 0.84 | PTPN1 (0.74) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL5163594 | 0.83 | PGK1 (0.59) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL7188019 | 0.82 | PGK1 (0.57) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL5892025 | 0.81 | PGK1 (0.56) | PGK1PGK2PTPN1PTPN2PTPN6 | |
| SCHEMBL5003956 | 0.78 | PTPN1 (0.67) | PGK1PGK2PTPN1PTPN2PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | claimed |