Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080755 | 0.91 | TARBP2 (0.42) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL8072434 | 0.88 | TARBP2 (0.38) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL7655614 | 0.85 | TARBP2 (0.35) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL8072656 | 0.84 | KDM4E (0.41) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL8085093 | 0.84 | KDM4E (0.43) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL8072645 | 0.83 | PDE1A (0.44) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL2954102 | 0.82 | KMT2A (0.48) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL7655361 | 0.82 | KDM4E (0.48) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL2954105 | 0.80 | ALDH1A1 (0.49) | KMT2AKDM4EALDH1A1MEN1TP53 | |
| SCHEMBL2955515 | 0.78 | ALDH1A1 (0.47) | KMT2AKDM4EALDH1A1MEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340704-B1 | TREATING NERVE DISEASE OR BONE/JOINT DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-01-22 | — | — | US | disclosed |
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |