Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRG | P48443 | 2/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663960 | 0.90 | PTPN1 (0.43) | PTPN1RXRARXRBRXRG | |
| SCHEMBL7593796 | 0.88 | PTPN1 (0.44) | PTPN1RXRARXRBRXRGPTPN5 | |
| SCHEMBL7592836 | 0.86 | PTPN1 (0.48) | PTPN1RXRARXRBRXRG | |
| SCHEMBL7597536 | 0.84 | PTPN1 (0.56) | PTPN1RXRARXRBRXRGPTPN2 | |
| SCHEMBL7596789 | 0.80 | PTPN1 (0.47) | PTPN1PTPN2 | |
| SCHEMBL7596371 | 0.79 | PTPN1 (0.53) | PTPN1RXRARXRBRXRGPTPN2 | |
| SCHEMBL7593786 | 0.79 | PTPN1 (0.40) | PTPN1RXRARXRBRXRG | |
| SCHEMBL7592832 | 0.76 | PTPN1 (0.44) | PTPN1RXRARXRBRXRG | |
| SCHEMBL7187448 | 0.76 | PTPN1 (0.47) | PTPN1PTPN2 | |
| SCHEMBL7198638 | 0.75 | ALDH1A1 (0.37) | PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | disclosed |