Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 6/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672877 | 0.94 | PDGFRA (0.41) | JAK2PTK2EGFRFGFR1CDK2 | |
| SCHEMBL7661658 | 0.87 | PDGFRA (0.38) | ADORA2ACDK2PDGFRACCNE1CDK1 | |
| SCHEMBL7661549 | 0.86 | PDGFRA (0.40) | JAK2PTK2EGFRFGFR1CDK2 | |
| SCHEMBL7661594 | 0.84 | CDK2 (0.43) | JAK2PTK2EGFRFGFR1CDK2 | |
| SCHEMBL7674302 | 0.84 | PDGFRA (0.44) | JAK2PTK2EGFRFGFR1ADORA2A | |
| SCHEMBL7674230 | 0.84 | TMIGD3 (0.42) | JAK2PTK2EGFRFGFR1TMIGD3 | |
| SCHEMBL7661510 | 0.82 | PDGFRA (0.41) | JAK2PTK2EGFRFGFR1CDK2 | |
| SCHEMBL7666161 | 0.81 | PDGFRA (0.41) | JAK2PTK2EGFRFGFR1CDK2 | |
| SCHEMBL7668775 | 0.80 | PDGFRA (0.42) | JAK2PTK2EGFRFGFR1CDK2 | |
| SCHEMBL7667620 | 0.80 | PDGFRA (0.41) | JAK2PTK2EGFRFGFR1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |