Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664347 | 0.94 | JAK2 (0.37) | PDGFRACCNE1CDK2JAK2PTK2 | |
| SCHEMBL7661549 | 0.92 | PDGFRA (0.40) | PDGFRACCNE1CDK2NR3C1CTSL | |
| SCHEMBL7661594 | 0.91 | CDK2 (0.43) | PDGFRACCNE1CDK2CTSLJAK2 | |
| SCHEMBL7674302 | 0.90 | PDGFRA (0.44) | PDGFRACCNE1CDK2NR3C1CTSL | |
| SCHEMBL7661510 | 0.88 | PDGFRA (0.41) | PDGFRACCNE1CDK2NR3C1CTSL | |
| SCHEMBL7666161 | 0.87 | PDGFRA (0.41) | PDGFRACCNE1CDK2CTSLJAK2 | |
| SCHEMBL7668775 | 0.86 | PDGFRA (0.42) | PDGFRACCNE1CDK2CTSLJAK2 | |
| SCHEMBL7670050 | 0.85 | CDK2 (0.45) | PDGFRACCNE1CDK2CTSLCDK1 | |
| SCHEMBL7667620 | 0.85 | PDGFRA (0.41) | PDGFRACCNE1CDK2CTSLJAK2 | |
| SCHEMBL7674135 | 0.85 | PDGFRA (0.43) | PDGFRACCNE1CDK2NR3C1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |