Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | IDH1 | O75874 | 10/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664856 | 1.00 | LCK (0.54) | LCKJAK2JAK3IDH1 | |
| SCHEMBL7663006 | 0.89 | LCK (0.45) | LCKJAK2JAK3IDH1 | |
| SCHEMBL7668093 | 0.88 | GABRA2 (0.56) | LCKJAK2JAK3IDH1 | |
| SCHEMBL7590690 | 0.88 | MAPK14 (0.52) | LCKIDH1 | |
| SCHEMBL7590696 | 0.88 | MAPK14 (0.52) | LCKIDH1 | |
| SCHEMBL7528721 | 0.80 | MAPK14 (0.54) | IDH1 | |
| SCHEMBL7665192 | 0.78 | MAPK14 (0.51) | LCKIDH1 | |
| SCHEMBL7665202 | 0.78 | MAPK14 (0.51) | LCKIDH1 | |
| SCHEMBL27581646 | 0.78 | LCK (0.53) | LCKJAK2JAK3IDH1 | |
| SCHEMBL6981895 | 0.78 | LCK (0.53) | LCKJAK2JAK3IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492516-B1 | PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF WHICH EXHIBIT UTILITY FOR THE TREATMENT OF CYTOKINE MEDIATED DISEASES SUCH AS ARTHRITIS. | MERCK & CO., INC. | 2002-12-10 | — | — | US | disclosed |