Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951608 | 1.00 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL8622977 | 1.00 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL7531520 | 0.92 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL4586034 | 0.90 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL8624507 | 0.89 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL7538514 | 0.89 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL6953765 | 0.89 | EDNRA (0.65) | EDNRAEDNRB | |
| SCHEMBL8621856 | 0.89 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL8175303 | 0.88 | EDNRA (0.57) | EDNRAEDNRB | |
| SCHEMBL7531947 | 0.86 | EDNRA (0.56) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441173-B1 | NOVEL INTERMEDIATES OF AND CONVERSION TO 3-(2-(2-HYDROXYETH-1-YLOXY) OR (2-CARBOXYMETHOXY)-4-METHOXYPHENYL)-1-(3,4-METHYLENE DIOXYPHENYL)-5-(PROP-1-YLOXY)INDANE-2-CARBOXYLIC ACID | SMITHKLINE BEECHAM CORPORATION | 2002-08-27 | — | — | US | disclosed |
| US-6162932-A | Stereoselective synthesis of endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-19 | — | — | US | disclosed |
| US-6080862-A | PREPARING (1S, 2R, 3S)-3-(2-HYDROXYETH-1-YLOXY)-4-METHOXYPHENYL) 1-(3,4-METHYLENEDIOXYPHENYL) 5-(PROP-1-YLOXY)INDANE-2-CARBOXYLIC ACID | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-27 | — | — | US | disclosed |