Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.58 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.42 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669520 | 1.00 | F2 (0.58) | F2TMPRSS6PRSS1TMPRSS15FTO | |
| SCHEMBL7676248 | 0.90 | F2 (0.57) | F2TMPRSS6PRSS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7671933 | 0.89 | F2 (0.56) | F2TMPRSS6 | |
| Acetic Acid SCHEMBL7663094 | 0.87 | TMPRSS6 (0.55) | F2TMPRSS6PRSS1TMPRSS15KLK1 | |
| Acetic Acid SCHEMBL7667840 | 0.87 | TMPRSS6 (0.55) | F2TMPRSS6PRSS1TMPRSS15KLK1 | |
| SCHEMBL7675632 | 0.86 | SMN1; SMN2 (0.51) | F2TMPRSS6TMPRSS15KDM4ENPC1 | |
| SCHEMBL7673733 | 0.86 | MAPT (0.49) | F2TMPRSS6KDM4ENPC1ALDH1A1 | |
| SCHEMBL7670445 | 0.84 | TMPRSS6 (0.51) | F2TMPRSS6PRSS1TMPRSS15GAA | |
| SCHEMBL7670690 | 0.84 | TMPRSS6 (0.51) | F2TMPRSS6PRSS1TMPRSS15GAA | |
| SCHEMBL7669728 | 0.82 | PLAU (0.45) | F2TMPRSS6PRSS1TMPRSS15KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |