Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 9/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 7/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 7/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665393 | 1.00 | ITGAL (0.41) | ITGALITGB2ICAM1TSHRMEN1 | |
| SCHEMBL7663042 | 0.88 | ITGAL (0.46) | ITGALITGB2ICAM1TSHRMEN1 | |
| SCHEMBL7663043 | 0.88 | ITGAL (0.46) | ITGALITGB2ICAM1TSHRMEN1 | |
| SCHEMBL7672836 | 0.82 | MCHR1 (0.38) | ITGALITGB2ICAM1 | |
| SCHEMBL18816258 | 0.72 | TSHR (0.50) | ITGALITGB2ICAM1TSHRMEN1 | |
| SCHEMBL22898531 | 0.67 | ITGB2 (0.44) | ITGALITGB2ICAM1TSHRMEN1 | |
| SCHEMBL22898545 | 0.67 | ITGB2 (0.44) | ITGALITGB2ICAM1TSHRMEN1 | |
| SCHEMBL22898533 | 0.67 | ITGAL (0.44) | ITGALITGB2ICAM1TSHRMEN1 | |
| SCHEMBL22898565 | 0.67 | ITGAL (0.44) | ITGALITGB2ICAM1TSHRMEN1 | |
| SCHEMBL18787397 | 0.67 | ITGB2 (0.44) | ITGALITGB2ICAM1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365615-B1 | DICHLOROPHENYL TETRAHYDROPYRROLO(1,2-C)IMIDAZOLE-1,3-DIONES; IMMUNE CELL MEDIATED CONDITIONS; ANTAGONISTS OF THE BINDING OF HUMON INTERCELLULAR ADHESION MOLECULES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-04-02 | — | — | US | claimed |
| US-6365615-B1 | DICHLOROPHENYL TETRAHYDROPYRROLO(1,2-C)IMIDAZOLE-1,3-DIONES; IMMUNE CELL MEDIATED CONDITIONS; ANTAGONISTS OF THE BINDING OF HUMON INTERCELLULAR ADHESION MOLECULES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-04-02 | — | — | US | disclosed |
| US-6365615-B1 | DICHLOROPHENYL TETRAHYDROPYRROLO(1,2-C)IMIDAZOLE-1,3-DIONES; IMMUNE CELL MEDIATED CONDITIONS; ANTAGONISTS OF THE BINDING OF HUMON INTERCELLULAR ADHESION MOLECULES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-04-02 | — | — | US | disclosed |
| WO-2001007052-A1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-02-01 | — | — | WO | disclosed |