Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 8/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5437774 | 0.87 | ADORA1 (0.43) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5431586 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5701832 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5431701 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5861429 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5860233 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5860446 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5861492 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5861525 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR | |
| SCHEMBL5428341 | 0.84 | ADORA2B (0.53) | ADORA2AADORA2BADORA1ADORA3MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355646-B1 | IMMUNOLOGY TREATMENT OF INFLAMMATORY CONDITIONS AND IMMUNE DISORDERS SEPTIC SHOCK | GLAXO WELLCOME INC. | 2002-03-12 | — | — | US | disclosed |