Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | PRKCA | P17252 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.51 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131381 | 0.86 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7670525 | 0.80 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4586510 | 0.77 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8113515 | 0.76 | CSNK1D (0.56) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8018918 | 0.74 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4583748 | 0.74 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4587201 | 0.74 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4586046 | 0.74 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8108392 | 0.74 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8108276 | 0.74 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414150-B1 | POTENT AND SELECTIVE INHIBITORS OF CSBP/P38/RK KINASE ACTIVITY; ANTIINFLAMMATORY AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414150-B1 | POTENT AND SELECTIVE INHIBITORS OF CSBP/P38/RK KINASE ACTIVITY; ANTIINFLAMMATORY AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-07-02 | — | — | US | disclosed |
| EP-1021173-A1 | USE OF CSAID?TM COMPOUNDS FOR THE MANAGEMENT OF UTERINE CONTRACTIONS | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999018942-A1 | USE OF CSAIDTM COMPOUNDS FOR THE MANAGEMENT OF UTERINE CONTRACTIONS | IMPERIAL COLLEGE INNOVATIONS LTD. (GB) | 1999-04-22 | — | — | WO | disclosed |