Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.62 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987464 | 0.86 | KDM4E (0.54) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL8131381 | 0.85 | MAPK14 (0.57) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL21621304 | 0.81 | L3MBTL1 (0.58) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL7665444 | 0.80 | MAPK14 (0.52) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL5850352 | 0.78 | MAPK14 (0.53) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL4974887 | 0.78 | MAPK14 (0.81) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL1554639 | 0.76 | MAPK14 (0.54) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL5769601 | 0.76 | MAPK14 (0.62) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL6579207 | 0.76 | MAPK14 (0.53) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL6619193 | 0.75 | MAPK14 (0.53) | MAPK14CSNK1DJAK3MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414150-B1 | POTENT AND SELECTIVE INHIBITORS OF CSBP/P38/RK KINASE ACTIVITY; ANTIINFLAMMATORY AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414150-B1 | POTENT AND SELECTIVE INHIBITORS OF CSBP/P38/RK KINASE ACTIVITY; ANTIINFLAMMATORY AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-07-02 | — | — | US | disclosed |
| EP-1021173-A1 | USE OF CSAID?TM COMPOUNDS FOR THE MANAGEMENT OF UTERINE CONTRACTIONS | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999018942-A1 | USE OF CSAIDTM COMPOUNDS FOR THE MANAGEMENT OF UTERINE CONTRACTIONS | IMPERIAL COLLEGE INNOVATIONS LTD. (GB) | 1999-04-22 | — | — | WO | disclosed |