Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665744 | 0.89 | OPRD1 (0.73) | OPRD1OPRK1OPRM1HDAC6KCNE1 | |
| SCHEMBL7673447 | 0.88 | OPRD1 (0.71) | OPRD1OPRK1OPRM1HDAC6KCNE1 | |
| SCHEMBL7672468 | 0.84 | OPRD1 (0.84) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7667352 | 0.83 | OPRD1 (0.85) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7665704 | 0.83 | OPRD1 (0.79) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7669862 | 0.82 | OPRD1 (1.00) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7673451 | 0.82 | OPRD1 (0.80) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7665748 | 0.82 | OPRD1 (0.82) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7671940 | 0.82 | OPRD1 (0.85) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7665853 | 0.81 | OPRD1 (0.73) | OPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444679-B1 | NEUROLOGICAL AND GASTROINTESTINAL DISORDERS; DELTA OPIOID LIGANDS OR OPIOID RECEPTORS | PFIZER INC | 2002-09-03 | — | — | US | disclosed |
| EP-1038872-A1 | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands | Pfizer Products Inc. (US) | 2000-09-27 | — | — | EP | disclosed |